The effectiveness of antioxidants in reducing paracetamol-induced damage subsequent to paracetamol activation.

  • Andrew W. Harman
  • Published 1985 in
    Research communications in chemical pathology and…


Paracetamol toxicity was studied in isolated mouse hepatocytes. This drug produced a concentration- and time-dependent loss of cell viability. Exposure to 5 mM paracetamol produced a rapid fall in intracellular reduced glutathione (GSH) followed by a decrease in plasma membrane integrity. The antioxidant, diphenyl-p-phenylenediamine (DPPD) had no effect on… (More)