The effectiveness of S9 and microsomal mix on activation of cyclophosphamide to induce genotoxicity in human lymphocytes.

@article{Kugler1987TheEO,
  title={The effectiveness of S9 and microsomal mix on activation of cyclophosphamide to induce genotoxicity in human lymphocytes.},
  author={U Kugler and Manfred Bauchinger and Ernst Schmid and Waltraud G{\"o}ggelmann},
  journal={Mutation research},
  year={1987},
  volume={187 3},
  pages={151-6}
}
Comparative results are presented on the effectiveness of rat-liver S9 or microsomal mix (M mix) in activating cyclophosphamide (CP) and its ability to induce a clastogenic effect in human lymphocytes in vitro. Structural chromosome changes were analysed exclusively in 1st division (M1) metaphases post-exposure. A high genotoxic response was observed for both metabolizing systems used. With an exposure of 2 h to different concentrations of S9 or M mix, the highest aberration yields were always… CONTINUE READING

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