The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects

@article{Kovarik2007TheEO,
  title={The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects},
  author={John M. Kovarik and Michael Y Lu and G Rivi{\`e}re and Irene Barbet and Steve Maton and D. Ronald Goldwater and Robert L. Schmouder},
  journal={European Journal of Clinical Pharmacology},
  year={2007},
  volume={64},
  pages={457-463}
}
The sphingosine-1-phosphate receptor modulator fingolimod (FTY720) is known to elicit a negative chronotropic effect at treatment initiation that attenuates over time with continued dosing. The authors determined the effect of combining a single dose of fingolimod with steady-state atenolol or diltiazem on heart rate and mean arterial pressure. In a partially randomized, single-blind, placebo-controlled, three-period, crossover study, 25 healthy subjects received (1) a single oral 5-mg dose of… CONTINUE READING

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