The effect on IgG glycosylation of altering beta1, 4-galactosyltransferase-1 activity in B cells.

@article{Keusch1998TheEO,
  title={The effect on IgG glycosylation of altering beta1, 4-galactosyltransferase-1 activity in B cells.},
  author={Jeremy Keusch and Peter M. Lydyard and Peter J. Delves},
  journal={Glycobiology},
  year={1998},
  volume={8 12},
  pages={1215-20}
}
An absence of galactose on the N-linked oligosaccharides of immunoglobulin G (IgG) has been shown to affect the functional activity of the antibody molecule. In patients with rheumatoid arthritis there is an increased proportion of IgG which lacks galactose and correspondingly lower levels of beta1, 4-galactosyltransferase (beta4Gal-T) activity. The recent… CONTINUE READING