The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia

@inproceedings{Balushi2018TheEO,
  title={The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia},
  author={Halima W. M. Al Balushi and David C Rees and John N. Brewin and Anke Hannemann and John S Gibson},
  booktitle={Physiological reports},
  year={2018}
}
Red cells from patients with sickle cell anemia (SCA) are under greater oxidative challenge than those from normal individuals. We postulated that oxidants generated by xanthine oxidase (XO) and hypoxanthine (HO) contribute to the pathogenesis of SCA through altering solute permeability. Sickling, activities of the main red cell dehydration pathways… CONTINUE READING