The effect of vitamin E on the intracellular distribution of the different oxidation states of selenium in rat liver.

  title={The effect of vitamin E on the intracellular distribution of the different oxidation states of selenium in rat liver.},
  author={Christine P. J. Caygill and Jack A. Lucy and A. T. Diplock},
  journal={The Biochemical journal},
  volume={125 2},
1. The liver intracellular distribution of (75)Se, (75)Se(2-) and (75)SeO(3) (2-) formed from orally administered Na(2) (75)SeO(3) was studied in rats given four different dietary treatments. 2. Subcellular fractionation was done by using sucrose density gradients in a B XIV zonal centrifuge rotor, and conditions were established so that separation of lysosomal, mitochondrial, smooth- and rough-surfaced endoplasmic reticulum, and soluble fractions was achieved. 3. Marker enzymes acid… 

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Possible stabilizing effect of vitamin E on microsomal, membrane-bound, selenide-containing proteins and drug-metabolizing enzyme systems
It will be shown that the inductive effect of phenobarbitone on the microsomal drug-metabolizing enzyme system of normal rats is accompanied by a large increase in the uptake of selenium and its conversion to selenide; when vitamin E is withdrawn from the diet, this effect cannot be demonstrated.
Interaction of vitamin E and selenium with the hepatotoxic agent dimethylnitrosamine.
Vitamin E could protect membranes from damage during the necrotizing action of DMNA and selenium pretreatment tended to decrease hepatic and plasma tocopherol levels.
Metabolic aspects of selenium action and toxicity.
The nutritional observations, on which the activity of selenium is based, are briefly reviewed, and the interactions of the trace element with vitamin E, polyunsaturated fatty acids, and sulfur amino
Effect of dietary phytate on growth and selenium status of chicks fed selenite or selenomethionine.
There is a positive relationship between phytate and selenium status in chicks, in contrast to its negative effect on growth, and the results suggest that there was greater deposition from selenomethionine than fromselenite and most was in non-reducible form.
The nutritional and metabolic roles of selenium and vitamin E
In a critical and detailed study of the antioxidant hypothesis, Green and co-workers could find little evidence that PUFA-exacerbated vitamin E deficiency was accompanied by increased destruction of I4C-labelled a-tocopherol, or by accumulation of lipid peroxides, the two criteria that had come to be regarded as implicit in the hypothesis.


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