The effect of vitamin E on the intracellular distribution of the different oxidation states of selenium in rat liver.

@article{Caygill1971TheEO,
  title={The effect of vitamin E on the intracellular distribution of the different oxidation states of selenium in rat liver.},
  author={Christine P. J. Caygill and Jack A. Lucy and A. T. Diplock},
  journal={The Biochemical journal},
  year={1971},
  volume={125 2},
  pages={
          407-16
        }
}
1. The liver intracellular distribution of (75)Se, (75)Se(2-) and (75)SeO(3) (2-) formed from orally administered Na(2) (75)SeO(3) was studied in rats given four different dietary treatments. 2. Subcellular fractionation was done by using sucrose density gradients in a B XIV zonal centrifuge rotor, and conditions were established so that separation of lysosomal, mitochondrial, smooth- and rough-surfaced endoplasmic reticulum, and soluble fractions was achieved. 3. Marker enzymes acid… 

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References

SHOWING 1-6 OF 6 REFERENCES
In Lyaosome8 in Biology and Pathology, vol
  • 2, p. 555. Ed. by Dingle, J. T. & Fell, H. B. Amsterdam and London: NorthHolland Publishing Co.
  • 1969
In Liver Function, pp
  • 528-534. Ed. by Brauer, R. W. Washington, D.C.: American Institute of
  • 1958
Biochim
  • biophys. Acta, 173, 554. Hinton, R.
  • 1969
Biochem . biophy 8 . Re 8
  • 1961
Biochem
  • J. 77, 326. Appelmans, M., Wattiaux, R. &
  • 1960
Nutr
  • Metab. 12, 358. Murakami, K. &
  • 1971