The effect of vitamin B12 on the anemia and combined system disease of addisonian pernicious anemia.

The effect of the parenteral administration of vitamin B(12) has been observed in eight patients with Addisonian pernicious anemia. Vitamin B(12) in initial doses of 50 micrograms or 25 micrograms induced satisfactory reticulocyte response and a return of erythrocyte count to within normal range in 60 days. In only two of the patients were secondary… (More)