Corpus ID: 25954554

The effect of vehicle formulation on acne medication tolerability.

  title={The effect of vehicle formulation on acne medication tolerability.},
  author={Z. Draelos and V. Callender and C. Young and S. Dhawan},
  volume={82 4},
Combination acne medications provide enhanced treatment opportunities. A commonly used acne therapy may combine a topical antibiotic with benzoyl peroxide (BPO) to prevent antibiotic resistance while optimizing control of microcomedone formation with a retinoid. Unfortunately, this combination of highly efficacious medications may cause irritation because of the inherent skin irritancy of BPO and retinoids. The present study was undertaken to determine if vehicle optimization of a clindamycin… Expand
Comparison of 2 clindamycin 1%-benzoyl peroxide 5% topical gels used once daily in the management of acne vulgaris.
Both formulations were effective in the treatment of inflammatory and noninflammatory acne lesions, but C/BPO HE produced a more consistent reduction in total inflammatory lesions over 12 weeks, which appears to improve patient tolerance and acceptance, which will likely help patients to comply with therapy. Expand
Lack of irritative potential of nadifloxacin 1% when combined with other topical anti‐acne agents
This work has shown that combining agents that target the different aetiological factors of acne can help increase efficacy and reduce response time, and the need to prevent development of bacterial resistance, requires new acne‐treatment combinations. Expand
Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris.
C/BPO HE achieves better overall treatment success in less time coupled with a significantly better tolerability profile and notably better safety profile, and despite the overall similar efficacy profile, C/B PO HE was better tolerated and safer than A/ BPO. Expand
An update on formulation strategies of benzoyl peroxide in efficient acne therapy with special focus on minimizing undesired effects.
A comprehensive overview of the published experimental vehicle systems for BPO is given to identify the fundamental rationales and to bring new developments in this dynamic field of research. Expand
Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed‐dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator‐blind, parallel‐group study
ClNP/BPO 3% showed greater efficacy for the early treatment of acne vulgaris in Japan, with a more favorable safety profile compared with ADA + CLNP. Expand
Evaluating clinical trial design: systematic review of randomized vehicle-controlled trials for determining efficacy of benzoyl peroxide topical therapy for acne
A systematic review of randomized vehicle-controlled trials evaluating the efficacy of topical benzoyl peroxide for the treatment of acne found that patient responses in randomized controlled trials evaluating topical acne therapies may be affected by clinical trial design, implementation, the biologic effects of vehicles, and natural disease progression. Expand
Moisturizers and Ceramide-containing Moisturizers May Offer Concomitant Therapy with Benefits.
It is proposed that adjunctive therapy with moisturizer, particularly ceramide-containing moisturizers, should be considered in acne-treated patients. Expand
Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%–Benzoyl Peroxide 3% Combination Gel
Results indicate that differences in BPO concentration do not influence clindamycin bioavailability, and systemic exposure to clind amycin and clind Amycin sulfoxide was low and comparable between the formulations. Expand
Clindamycin phosphate 1·2%–benzoyl peroxide 3·0% fixed‐dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single‐blinded, active‐controlled, parallel‐group study
A topical fixed‐dose clindamycin phosphate 1·2% and benzoyl peroxide 3·0% combination gel (CLNP/BPO 3%) is known to be effective and safe in white people with acne.
A multicentre, randomized, single‐blind comparison of topical clindamycin 1%/benzoyl peroxide 5% once‐daily gel versus clindamycin 1% twice‐daily gel in the treatment of mild to moderate acne vulgaris in Chinese patients
  • J. Xu, Q. Lu, +22 authors A. Hamedani
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2016
A large number of Chinese adolescents are affected by acne vulgaris, and combination therapy has become the recommended standard of care for acne treatment. Expand


Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: combined results of two double-blind investigations.
The combination gel was significantly superior to the two individual agents in global improvement and reduction of inflammatory lesions and also to the clindamycin gel in reducing noninflammatory lesions. Expand
Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial
Topical benzoyl peroxide and benzoyL peroxide/erythromycin combinations are similar in efficacy to oral oxytetracyclines and minocycline and are not affected by propionibacterial antibiotic resistance. Expand
Antibiotic resistance in the topical treatment of acne vulgaris.
Factors associated with the development of resistant P acnes following treatment with topical antibiotics, clinical relevance of antibiotic resistance, and strategies to reduce the incidence of P Acnes resistance are discussed in this review. Expand
Management of acne: a report from a Global Alliance to Improve Outcomes in Acne.
A method to evaluate skin moisturizers in vivo.
  • R. Rietschel
  • Chemistry, Medicine
  • The Journal of investigative dermatology
  • 1978
By applying the moisturizers to plastic film and the skin, it can be demonstrated that water is not detectable after a few minutes on the plastic, but is detectable on skin at higher than control (transepidermal water loss) values for several hours. Expand
Skin Moisturizers. II. The Effects of
Synopsis-The four parameters described in Part I of this study, i.e., elastic modulus, relaxation function, water absorption, and water vapor transmission, have been used to study the effect ofExpand
Dry skin: Moisturizing and emolliency