Corpus ID: 42018899

The effect of variations of pH upon the activation of phosphorylase by epinephrine in perfused contracting heart, liver slices and skeletal muscle.

@article{Reynolds1967TheEO,
  title={The effect of variations of pH upon the activation of phosphorylase by epinephrine in perfused contracting heart, liver slices and skeletal muscle.},
  author={R. Reynolds and N. Haugaard},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1967},
  volume={156 3},
  pages={
          417-25
        }
}
  • R. Reynolds, N. Haugaard
  • Published 1967
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The effect of variations of pH upon epinephrine activation of phosphorylase was studied in isolated perfused rat hearts as well as in diaphragms and liver slices incubated in vitro . The action of epinephrine upon phosphorylase was significantly enhanced in all three tissues by an increase of pH from 6.9 to 7.8. In the perfused heart, the increase in the metabolic effect of epinephrine with a rise in pH was associated with an increase in the inotropic action of the hormone. In diaphragm, an… CONTINUE READING

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