The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review

@article{Li2019TheEO,
  title={The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review},
  author={Yuanfa Li and Fangjuan Du and Dou Fu},
  journal={Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association},
  year={2019},
  volume={25},
  pages={218 - 228}
}
  • Yuanfa LiFangjuan DuD. Fu
  • Published 1 July 2019
  • Medicine
  • Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
Background/Aim: To assess the efficacy and safety of simethicone with or without N-acetylcysteine (NAC) as premedications before gastroscopy. Materials and Methods: We searched EMBASE, PubMed, Cochrane library and Web of Science database for randomized clinical controlled trials regarding simethicone ± NAC as oral drinking agents before gastroscopy. Statistical software RevMan5.3 was used for statistical analysis. Results: Ten randomized clinical trials that fulfilled the inclusion criteria… 
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The findings of current study on 1,099 patients successfully demonstrate that the pre-procedure oral administration of Simethicone ± N-acetylcysteine improves mucosal visualization and mucosal visualize score during OGD.

Premedication with simethicone and N-acetylcysteine for improving mucosal visibility during upper gastrointestinal endoscopy in a Western population

Data from this study show that premedication with simethicone and N-acetylcysteine results in significantly better endoscopic visualization of gastric mucosa, and the proposed Crema Stomach Cleaning Score could be useful for standardizing this evaluation.

Effectiveness of Premedication with Simethicone During Esophagogastroduodenoscopy

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Cohorts of premedication for endoscopy of the upper gastrointestinal tract with simethicone, N-acetylcysteine, Hedera helix and visual scale validation

The most effective solution as a premedication to achieve excellent visibility of the digestive mucosa was that used in the C4 cohort, which had better efficiency compared to the C3, C5 and C6 cohorts in that order.

Pre-Endoscopy Drink of Simethicone and N-Acetylcysteine Significantly Improves Visualization in Upper Gastrointestinal Endoscopy

A pre-endoscopy drink of NAC with simethicone can significantly improve mucosal visibility during UGIE and is safe, cheap, easily available and maybe considered for routine utilization for ensuring optimal endoscopic outcomes.

Cohortes de premedicación en endoscopia alta con Simeticona, N-acetylcisteina, Hedera helix y validación de escala visual

The most effective solution as a premedication to achieve excellent visibility of the digestive mucosa was that used in the C4 cohort, which had better efficiency compared to the C3, C5 and C6 cohorts in that order and is a very complete and easy tool to apply by more than one observer.

Premedication with simethicone for improving the quality of gastric mucosal visualization: a double-blind randomized controlled trial

Premedication with simethicone before upper gastrointestinal endoscopy significantly improves the quality of GMV without affecting the duration of the examination, patient satisfaction, and the rate of side effects.

Unfortunate-Premedication with simethicone for improving the quality of gastric mucosal visualization: a double-blind randomized controlled trial

Saliva, bubbles, or mucus can limit gastric mucosal visualization (GMV), increasing the risk of missed lesions such as gastric cancer and mucolytic and defoaming agents.

Minimizing the Risks of Simethicone in Endoscope Reprocessing

This paper was written as a companion to the new guidelines with a focus on minimizing the risks of simethicone in endoscope reprocessing.

A root cause analysis system to establish the most plausible explanation for post-endoscopy upper gastrointestinal cancer

Missed opportunities to avoid PEUGIC were identified in 71 % of cases and can standardize future investigation of PEUGic and guide quality improvement efforts.

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Improving the mucosal visualization at gastroscopy: a systematic review and meta-analysis of randomized, controlled trials reporting the role of Simethicone ± N-acetylcysteine.

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