The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis.

@article{Corpechot2000TheEO,
  title={The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis.},
  author={Christophe Corpechot and Fabrice Carrat and A M Bonnand and Ren{\'e}e Eug{\'e}nie Poupon},
  journal={Hepatology},
  year={2000},
  volume={32 6},
  pages={1196-9}
}
Ursodeoxycholic acid (UDCA) is the only approved treatment for primary biliary cirrhosis (PBC). However, the benefit from UDCA therapy on the progression of PBC from its early stage towards extensive fibrosis and cirrhosis has not been clearly shown. The aim of this study was to assess the effect of UDCA therapy on liver fibrosis progression in PBC. A Markov model was used to analyze the progression rates between early and late histologic stages in 103 patients with PBC enrolled in a randomized… CONTINUE READING

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