The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors.

@article{Crema2013TheEO,
  title={The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors.},
  author={Leonardo Machado Crema and Let{\'i}cia Ferreira Pettenuzzo and Michele Schlabitz and Lu{\'i}sa Am{\'a}lia Diehl and Juliana Bender Hoppe and R{\'e}gis Gemerasca Mestriner and Daniela Pereira Laureano and Christianne Gazzana Salbego and Carla Dalmaz and Deusa Aparecida Vendite},
  journal={Physiology & behavior},
  year={2013},
  volume={109},
  pages={1-7}
}
This study examined the effects of two chronic stress regimens upon depressive-like behavior, A(1) and A(2A) adenosine receptor binding and immunocontent. Male rats were subjected to unpredictable chronic mild stress (UCMS) or to chronic restraint stress (CRS) for 40 days. Subsequently, depressive-like behaviors (forced swimming and consumption of sucrose) were evaluated, and A(1) adenosine or A(2A) adenosine receptors were examined in the hippocampus or striatum, respectively. UCMS animals… CONTINUE READING
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