The effect of unilateral pneumonectomy on in vitro drug metabolism by the contralateral lung of rabbits.

Abstract

The effect of unilateral pneumonectomy on the drug-metabolizing capability of the remaining lung of male rabbits was studied 3, 10, and 28 days after surgery. During the period of compensatory lung growth which follows pneumonectomy, the contralateral lung had a reduced ability to metabolize some model drug substrates. The activities of 4-chloro-N… (More)

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@article{Mimnaugh1979TheEO, title={The effect of unilateral pneumonectomy on in vitro drug metabolism by the contralateral lung of rabbits.}, author={Edward G. Mimnaugh and Zahid H. Siddik and Michael A. Trush and Renee Drew and Trine Gram}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={1979}, volume={7 4}, pages={208-10} }