The effect of ultraviolet (UV) A1, UVB and solar‐simulated radiation on p53 activation and p21Waf1/Cip1

@article{Beattie2005TheEO,
  title={The effect of ultraviolet (UV) A1, UVB and solar‐simulated radiation on p53 activation and p21Waf1/Cip1},
  author={Paula E Beattie and Lee E. Finlan and N M Kernohan and G Thomson and Ted R. Hupp and Sally Helen Ibbotson},
  journal={British Journal of Dermatology},
  year={2005},
  volume={152}
}
Background  High‐dose ultraviolet (UV) A1 therapy (doses in the order of 130 J cm−2) is effective for atopic dermatitis and scleroderma. UVA1 has been shown to induce a dose‐dependent increase in p53 expression in keratinocytes. 
Topical nutlin‐3a does not decrease photocarcinogenesis induced by simulated solar radiation in hairless mice
Nutlin‐3a increases p53 levels after UVB radiation, which could result in a decrease in DNA damage and thus lead to a lower risk of non‐melanoma skin cancer. Especially, organ transplant recipientsExpand
Differential effects of 5‐aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo
TLDR
This work has shown that the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)‐induced skin cancer in animal models and p53 protein stabilization is induced after solar‐simulated irradiation of human skin in vivo. Expand
Green tea extract reduces induction of p53 and apoptosis in UVB‐irradiated human skin independent of transcriptional controls
TLDR
Topical GTE (OM24®) reduces UVB‐mediated epithelial damage already at low, cosmetically usable concentrations, without tachyphylaxis over 5 weeks, suggesting GTE as suitable everyday photochemopreventive agents. Expand
Activation of molecular adaptation to sunlight--a new approach to photoprotection.
  • G. Halliday
  • Chemistry, Medicine
  • The Journal of investigative dermatology
  • 2005
TLDR
This study shows that p53 helps the skin adapt to UVB by initiating protective measures, and proposes that low-dose UVB upregulates and stabilizes p53, which induces cell cycle arrest via p21/WAF1 induction and enhancement of DNA repair via increases in p53R2. Expand
Anticarcinogenic effect of ferulic acid on ultraviolet-B irradiated human keratinocyte HaCaT cells.
TLDR
Results indicate that Ferulic acid may have the potential anti-carcinogenic properties on the UVB induced epidermic tumor development by blocking the relevant cytokine secretion and expression of p53, p21, c-fos, PCNA and RPA genes. Expand
Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean.
TLDR
Environmental doses of UV can cause apoptosis by increasing p53 and decreasing p21, revealing an UV-damage pathway for U. cordatus, according to the apoptotic cascade of events. Expand
Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation
TLDR
It is demonstrated that the elements of the p53 cellular response evoked by exposure to UV radiation are wavelength dependent, which has important implications not only for understanding the mode of action of p53 but also for the use of molecular endpoints in quantifying exposure to different wavelengths of UV in the context of human health protection. Expand
In vitro models for investigating keratinocyte responses to ultraviolet B radiation
TLDR
This thesis describes the use of 2- and 3-dimensional cell-based models for studying how skin cells respond to ultraviolet radiation to investigate skin damage and repair after exposure to radiation in the context of skin cancer development. Expand
New applications of UVA-1 cold light therapy
TLDR
It is described that after 4 weeks of UVA-1 patients were better capable to maintain clinical improvement than after 3 weeks of therapy, and UVA 1 therapy proved to be better than placebo therapy in patients with dyshidrotic eczema. Expand
Cross‐validation of Murine UV Signal Transduction Pathways in Human Skin †
TLDR
The data suggest that UVB acts through MAPK p38 and PI‐3 kinase with phosphorylation of MAPKAPK‐2, CREB, c‐JUN, p38, GSK‐3β and p53 leading to marked increases in c‐FOS, COX‐2 and apoptosis. Expand
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Summary Background Ultraviolet radiation (UVR) damages keratinocytes. Direct DNA damage may undergo enzymatic repair followed by resumption of the normal cell cycle. Cells may also be eliminatedExpand
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TLDR
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TLDR
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TLDR
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TLDR
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