The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells

@article{Wieder1995TheEO,
  title={The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells},
  author={Thomas Wieder and Anne M Haase and Christoph C. Geilen and Constantin E. Orfanos},
  journal={Lipids},
  year={1995},
  volume={30},
  pages={389-393}
}
The concentration-dependent effects of two different synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis were compared in Madin-Darby canine kidney (MDCK) cells. The alkyllysophospholipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine and the alkylphosphocholine, hexadecylphosphocholine, inhibited cell proliferation with half-inhibitory concentrations (IC50) of 75 and 135 μmol/L, respectively. The agents also inhibited phosphatidylcholine biosynthesis in… CONTINUE READING
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