The effect of two genes on anesthetic response in the nematode Caenorhabditis elegans.

@article{Morgan1988TheEO,
  title={The effect of two genes on anesthetic response in the nematode Caenorhabditis elegans.},
  author={Philip G Morgan and Margaret M Sedensky and Philip M. Meneely and H. F. Cascorbi},
  journal={Anesthesiology},
  year={1988},
  volume={69 2},
  pages={246-51}
}
The authors studied the wild type strain, N2, and three mutant strains of the nematode, Caenorhabditis elegans, in order to measure genetically produced changes in responses to nine volatile anesthetics. They determined the anesthetic ED50s of N2 for thiomethoxyflurane, methoxyflurane, chloroform, halothane, enflurane, isoflurane, fluroxene, flurothyl, and diethylether. The log-log relationship of the oil-gas partition coefficients (O/G) and the ED50s of these agents for N2 yields a straight… CONTINUE READING