The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling.

@article{Yamaguchi2003TheEO,
  title={The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling.},
  author={Koichi Yamaguchi and Katsuhiro Higashiura and Nobuyuki Ura and Hideyuki Murakami and Masaya Hyakukoku and Masato Furuhashi and Kazuaki Shimamoto},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2003},
  volume={26 5},
  pages={389-96}
}
Recent studies have indicated that tumor necrosis factor (TNF)-alpha plays a significant role in insulin resistance. It has been proposed that selective impairment of insulin signaling in glucose metabolism is related to the development of atherosclerosis, although the mechanisms are not clear. The aim of this study was to elucidate the effect of TNF-alpha on tissue specificity and selectivity to insulin signaling. L6 myotubes and rat aortic vascular smooth muscle cells (VSMC) were cultured… CONTINUE READING
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