The effect of tumor-derived exosomes on immune regulation and cancer immunotherapy.

@article{Whiteside2017TheEO,
  title={The effect of tumor-derived exosomes on immune regulation and cancer immunotherapy.},
  author={Theresa L Whiteside},
  journal={Future oncology},
  year={2017},
  volume={13 28},
  pages={
          2583-2592
        }
}
Tumor-derived exosomes (TEX) carry both immunosuppressive and immunostimulatory receptor/ligands that in part mimic the profiles of the parent tumor cells. Operating as an intercellular communication system, TEX deliver protumor or antitumor signals to immune and nonimmune cells reprogramming their functions. Mechanisms responsible for cellular reprogramming include cell surface signaling and/or uptake of TEX by recipient cells. Once internalized, TEX transfer mRNA, miRNA and proteins that… CONTINUE READING

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