The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals.

@article{Petrakis2002TheEO,
  title={The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals.},
  author={Ismene L Petrakis and Alessandra Buonopane and Stephanie O'malley and Omer Cermik and Louis A Trevisan and Nash N. Boutros and Diana D Limoncelli and John H. Krystal},
  journal={Alcoholism, clinical and experimental research},
  year={2002},
  volume={26 7},
  pages={969-75}
}
BACKGROUND Alcohol self-administration in the laboratory has been used to evaluate pharmacological treatments and neurobiological mechanisms that underlie alcohol use in alcohol-dependent individuals. This study evaluated whether attenuation of serotonin synthesis via depletion of its precursor tryptophan reduces the amount of alcohol consumed in a self-administration paradigm in non-treatment-seeking individuals with alcohol use disorders. METHODS Individuals with alcohol dependence (n = 8… CONTINUE READING