The effect of troleandomycin on methylprednisolone elimination.

  title={The effect of troleandomycin on methylprednisolone elimination.},
  author={Stanley J Szefler and James Rose and Elliot F Ellis and Sheldon Laurence Spector and A. W. Green and William J. Jusko},
  journal={The Journal of allergy and clinical immunology},
  volume={66 6},
Troleandomoycin (TAO), a macrolide antibiotic, has an apparent "steroid-sparing" effect when used in the treatment of severe steroid-dependent asthma. This study was designed to investigate the effect of TAO on methylprednisolone elimination. Pharmacokinetic studies were performed before and 1 wk after starting TAO in 10 severe steroid-dependent asthmatics. Baseline total body clearance of methylprednisolone was 406 +/- 139 (mean +/- SD) ml/min/1.73 m2 and decreased significantly (p < 0.001) to… CONTINUE READING
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