• Corpus ID: 30110157

The effect of trimethoprim on potassium and uric acid metabolism in normal human subjects.

  title={The effect of trimethoprim on potassium and uric acid metabolism in normal human subjects.},
  author={Burl R. Don},
  journal={Clinical nephrology},
  volume={55 1},
  • B. Don
  • Published 2001
  • Medicine, Biology
  • Clinical nephrology
BACKGROUND Trimethoprim used in combination with other antibiotics, has been implicated in causing hyperkalemia and hypouricemia in patients with acquired immune deficiency syndrome (AIDS). In experimental animal models, trimethoprim has been demonstrated to block sodium channels and Na+-K+-ATPase in the distal nephron and thus impair potassium excretion. Although the data from the experimental models suggest that trimethoprim reduces urinary potassium excretion, the retrospective clinical… 
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