The effect of treatment with coenzyme Q10 on the mitochondrial function and superoxide radical formation in cardiac muscle hypertrophied by mild aortic stenosis.

@article{Guarnieri1987TheEO,
  title={The effect of treatment with coenzyme Q10 on the mitochondrial function and superoxide radical formation in cardiac muscle hypertrophied by mild aortic stenosis.},
  author={C. Richard Guarnieri and Claudio Muscari and Stefano Manfroni and Ilaria Caldarera and Claudio Stefanelli and E Pretolani},
  journal={Journal of molecular and cellular cardiology},
  year={1987},
  volume={19 1},
  pages={63-71}
}
A 40% reduction of the diameter of the ascending aorta maintained for 60 days induced the formation of a compensate cardiac hypertrophy in rabbits without changing the value of the azide insensitive Ca2+-ATPase activity in comparison to control hearts. The cardiac mitochondria isolated from constricted animals assayed in presence of glutamate and succinate did not show a change in the R.C.I. and ADP/O values in comparison to the controls, whilst the QO2 value enhanced or decreased respectively… CONTINUE READING