The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury

@article{Kalmar2003TheEO,
  title={The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury},
  author={Bernadett Kalmar and Linda Greensmith and Marzia Malcangio and Stephen B. McMahon and P{\'e}ter Csermely and Geoffrey Burnstock},
  journal={Experimental Neurology},
  year={2003},
  volume={184},
  pages={636-647}
}

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Treatment with BRX-220, a co-inducer of hsps, protects motoneurones from axotomy-induced cell death and results in a significant increase in the expression of hsp70 and hsp90 in glia and neurones.
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Application of exogenous Hsc70 prevented axotomy-induced death of virtually all sensory neurons, but did not significantly alter motoneuron death, suggesting that HSc70 may prove to be useful in the repair of peripheral sensory nerve damage.
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TLDR
It is possible that the upregulation of hsp27 observed in injured mot oneurones may play a role in protecting motoneurones from apoptotic cell death following nerve injury, as assessed by TUNEL and caspase-3 immunoreactivity.
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