The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury.

@article{Kalmr2003TheEO,
  title={The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury.},
  author={Bernadett Kalm{\'a}r and Linda Greensmith and Marzia Malcangio and Stephen B. McMahon and P{\'e}ter Csermely and Geoffrey Burnstock},
  journal={Experimental neurology},
  year={2003},
  volume={184 2},
  pages={636-47}
}
In this study, we examined the effect BRX-220, a co-inducer of heat shock proteins, in injury-induced peripheral neuropathy. Following sciatic nerve injury in adult rats and treatment with BRX-220, the following features of the sensory system were studied: (a) expression of calcitonin gene-related peptide (CGRP); (b) binding of isolectin B4 (IB4) in dorsal root ganglia (DRG) and spinal cord; (c) stimulation-evoked release of substance P (SP) in an in vitro spinal cord preparation and (d… CONTINUE READING
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