The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat.

@article{Kamm2006TheEO,
  title={The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat.},
  author={Keira Kamm and Wayne E Vanderkolk and Chuck Lawrence and Mark A Jonker and Alan T. Davis},
  journal={The Journal of trauma},
  year={2006},
  volume={60 1},
  pages={152-7}
}
BACKGROUND Using a model of traumatic brain injury (TBI) in the rat, this study was undertaken to characterize the short-term biochemical changes of IL-1beta, IL-10, and tumor necrosis factor TNF-alpha to determine whether injury in the brain elicits a systemic cytokine response. METHODS Sprague-Dawley rats were subjected to a TBI using a weight-drop model and then killed at various time points after injury. Samples of blood, brain, and liver were recovered and analyzed for concentrations of… CONTINUE READING

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