The effect of tissue and cellular pH on the selective biodistribution of porphyrin-type photochemotherapeutic agents: a volumetric titration study.

@article{Barrett1990TheEO,
  title={The effect of tissue and cellular pH on the selective biodistribution of porphyrin-type photochemotherapeutic agents: a volumetric titration study.},
  author={A. J. Barrett and James C. Kennedy and R. A. Y. Jones and Pierre Nadeau and Roy H. Pottier},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={1990},
  volume={6 3},
  pages={
          309-23
        }
}
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The possible role of ionic species in selective biodistribution of photochemotherapeutic agents toward neoplastic tissue.
The Effect of pH on the Topography of Porphyrins in Lipid Membranes ¶
The effect of the acidity of the environment on the topography and photophysics of sensitizer molecules in homogeneous solutions, and when embedded in a lipid microenvironment, was studied. Four…
The Effect of pH on the Topography of Porphyrins in Lipid Membranes¶
TLDR
The quenching efficiency in liposomes, relative to the quenched in buffer, as a function of pH, shows that porphyrins in the neutral form penetrate deeper inside the lipid bilayer and are less exposed to external quench than when negatively charged at the carboxylic moiety.
Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state.
Photophysical properties of porphyrins in biological membranes.
  • F. Ricchelli
  • Chemistry, Biology
    Journal of photochemistry and photobiology. B, Biology
  • 1995
Interaction of hematoporphyrin with lipid membranes.
TLDR
This study considers the properties of hematoporphyrin (Hp), a well-known photosensitizer for PD and PDT, in the presence of a 1-palmitoyl-2-oleoysl-sn-glycero-3-phosphocholine (POPC) bilayer that is used as a model system for protein-free cell membranes and provides a more detailed molecular-level description of the interactions of photosensitism with lipid membranes.
Interaction of Dicarboxylic Metalloporphyrins with Liposomes. The Effect of pH on Membrane Binding Revisited ¶
TLDR
Results indicate that the porphyrins partition into the membrane with their carboxylic moieties near the lipid–water interface so that their deprotonation, leading to a charged molecule, does not prevent the insertion of the tetrapyrrole ring into the lipid environment of neutral liposomes.
Interaction of Dicarboxylic Metalloporphyrins with Liposomes. The Effect of pH on Membrane Binding Revisited¶
TLDR
Results indicate that the porphyrins partition into the membrane with their carboxylic moieties near the lipid–water interface so that their deprotonation, leading to a charged molecule, does not prevent the insertion of the tetrapyrrole ring into the lipid environment of neutral liposomes.
pH-Dependent Modification of Lipophilicity of Porphyrin-type Photosensitizers
Abstract Structural modifications of photosensitizers (changes in protonation, ionic state and aggregation state) under different environmental conditions should be precisely determined to understand…
Laser Excited Fluorescence Lifetimes of Hematoporphyrin IX as a Function of Solution pH: Implication in Photodynamic Therapy
TLDR
The fluorescence lifetimes of hematoporphyrin IX were evaluated as a function of both pH and concentration to assess the role of monomeric and dimeric species in the selective biodistribution of drugs toward tumor tissue.
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References

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Equilibrium and kinetic studies of the aggregation of porphyrins in aqueous solution.
TLDR
The ability of a particular porphyrin to dimerize appears to parallel that of the corresponding iron(III) complexes (ferrihaems), although it is thought that ferrihaem do not exhibit further aggregation under these conditions.
Spectrofluorimetric study of porphyrin incorporation into membrane models--evidence for pH effects.
Some preparations and properties of porphyrins.
TLDR
The ability of porphyrins to act as photosensitizers, especially in the production of highly reactive singlet oxygen which in turn exerts cytotoxic action, has been used extensively in the novel treatment of malignant tissue, a technique referred to as photoradiation therapy (PRT).
Chapter II - Physico-chemical Properties of Porphyrins
GLUCOSE ADMINISTRATION AUGMENTS IN VIVO UPTAKE AND PHOTOTOXICITY OF THE TUMOR‐LOCALIZING FRACTION OF HEMATOPORPHYRIN DERIVATIVE
Abstract Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of…
pH distribution in human tumors.
PORPHYRIN PHOTOSENSITIZATION AND PHOTOTHERAPY
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  • Education
    Photochemistry and photobiology
  • 1986
TLDR
The literature in the field of porphyrin photosensitization has been growing with an increasing rate since the last yearly review on the topic was published in this journal, and this field will receive significant attention in the present review.
HEMATOPORPHYRIN and HPD: PHOTOPHYSICS, PHOTOCHEMISTRY and PHOTOTHERAPY
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  • Biology
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  • 1984
TLDR
The topic of porphyrin photosensitization was reviewed in this Journal three years ago as part of a commentary on photodynamic dye action and a substantial amount of new literature has appeared during the intervening years.
Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.
TLDR
Polarographic measurements of the local tissue oxygen tension (PO2) using gold microelectrodes reveal that very low PO2 values are prevalent in C3H mouse mammary carcinomas, and clear heterogeneities in the pH distribution do occur.
Effect of CO2 and lactic acid on intracellular pH of ascites tumor cells.
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