The effect of three different oral doses of verapamil on the disposition of theophylline

@article{Stringer2005TheEO,
  title={The effect of three different oral doses of verapamil on the disposition of theophylline},
  author={Kathleen A. Stringer and Jane Mallet and M. Clarke and Jo Ann Lindenfeld},
  journal={European Journal of Clinical Pharmacology},
  year={2005},
  volume={43},
  pages={35-38}
}
SummaryResults of previous studies suggest that the theophylline-verapamil drug interaction may be dependent on verapamil dose. Therefore, in a randomized four-way cross over study, 12 healthy males received theophylline, as a single intravenous dose of aminophylline, alone (phase I) and after a four day regimen of oral verapamil 40 mg (phase II), 80 mg (phase III), and 120 mg (phase IV) every 8 h. Serial blood samples were collected over a 24 hour period for determination of serum theophylline… 

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