The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.

@article{Yu2002TheEO,
  title={The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.},
  author={Joseph G. Yu and Sandrine Javorschi and Andrea L. Hevener and Yolanta T. Kruszynska and Rodney A Norman and Madhur K. Sinha and Jerrold M. Olefsky},
  journal={Diabetes},
  year={2002},
  volume={51 10},
  pages={2968-74}
}
The insulin-sensitizing effects of thiazolidinediones are thought to be mediated through peroxisome proliferator-activated receptor-gamma, a nuclear receptor that is highly abundant in adipose tissue. It has been reported that adipocytes secrete a variety of proteins, including tumor necrosis factor-alpha, resistin, plasminogen activator inhibitor-1, and adiponectin. Adiponectin is a fat cell-secreted protein that has been reported to increase fat oxidation and improve insulin sensitivity. Our… CONTINUE READING
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