The effect of the uremic toxin cyanate (CNO⁻) on anaerobic cysteine metabolism and oxidative processes in the rat liver: a protective effect of lipoate.

@article{Sokoowska2011TheEO,
  title={The effect of the uremic toxin cyanate (CNO⁻) on anaerobic cysteine metabolism and oxidative processes in the rat liver: a protective effect of lipoate.},
  author={Maria M Sokołowska and Ewa Niedzielska and Małgorzata B Iciek and Anna Bilska and Elżbieta Lorenc-Koci and Lidia B Włodek},
  journal={Toxicology mechanisms and methods},
  year={2011},
  volume={21 6},
  pages={
          473-8
        }
}
Chronic renal failure (CRF) patients have an increased plasma level of urea, which can be a source of cyanate. This compound can cause protein carbamoylation thereby changing biological activity of proteins. Therefore, in renal failure patients, cyanate can disturb metabolism and functioning of the liver. This work presents studies demonstrating that the treatment of rats with cyanate alone causes the following changes in the liver: (1) inhibition of rhodanese (TST), cystathionase (CST) and 3… CONTINUE READING
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