The effect of the signalling scheme on the robustness of pattern formation in development

  title={The effect of the signalling scheme on the robustness of pattern formation in development},
  author={Hye-Won Kang and L. Zheng and H. Othmer},
  journal={Interface Focus},
  pages={465 - 486}
  • Hye-Won Kang, L. Zheng, H. Othmer
  • Published 2012
  • Computer Science, Medicine
  • Interface Focus
  • Pattern formation in development is a complex process which involves spatially distributed signals called morphogens that influence gene expression and thus the phenotypic identity of cells. Usually different cell types are spatially segregated, and the boundary between them may be determined by a threshold value of some state variable. The question arises as to how sensitive the location of such a boundary is to variations in properties, such as parameter values, that characterize the system… CONTINUE READING
    15 Citations
    Mechanisms of scaling in pattern formation
    • 80
    • PDF
    Core regulatory network motif underlies the ocellar complex patterning in Drosophila melanogaster
    • 5
    • PDF
    Stochastic Analysis of Reaction–Diffusion Processes
    • 17
    • PDF
    The Role of Mathematical Models in Understanding Pattern Formation in Developmental Biology
    • 23
    • PDF
    Single-cell resolution of intracellular T cell Ca2+ dynamics in response to frequency-based H2O2 stimulation.
    • 6
    External noise control in inherently stochastic biological systems.
    • 9
    • PDF


    Temporal dynamics of patterning by morphogen gradients.
    • 67
    Mechanisms for positional signalling by morphogen transport: a theoretical study.
    • 173
    A mathematical model for outgrowth and spatial patterning of the vertebrate limb bud.
    • 77
    • PDF
    A theory of biological pattern formation
    • 1,965
    • PDF
    Analysis of dynamic morphogen scale invariance
    • D. Umulis
    • Biology, Medicine
    • Journal of The Royal Society Interface
    • 2009
    • 35
    • PDF
    Do morphogen gradients arise by diffusion?
    • 396
    • PDF
    Robust, bistable patterning of the dorsal surface of the Drosophila embryo.
    • 116
    • PDF
    Pre-Steady-State Decoding of the Bicoid Morphogen Gradient
    • 180
    • PDF
    Dynamic control of positional information in the early Drosophila embryo
    • 533
    • PDF
    Kinetics of Morphogen Gradient Formation
    • 322
    • PDF