The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice.

@article{Redrobe1996TheEO,
  title={The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice.},
  author={John Paul Redrobe and Patrick Pinot and Michel S Bourin},
  journal={Fundamental & clinical pharmacology},
  year={1996},
  volume={10 6},
  pages={
          524-8
        }
}
The forced swimming test (FST) is a widely used behavioural model to predict potential antidepressant (AD) action of compounds in humans. It has been previously shown that pretreatment with lithium, quinine and clonidine had additive effects on AD drugs in the FST, an effect proposed to be a result of potassium channel blockade. It is possible that pretreatment with potassium channel openers may induce opposite effects to those seen following pretreatment with potassium channel blockers in the… CONTINUE READING
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