The effect of the neonatal Fc receptor on human IgG biodistribution in mice.

@article{Chen2014TheEO,
  title={The effect of the neonatal Fc receptor on human IgG biodistribution in mice.},
  author={Nancy Chen and Weirong Wang and Scott E. Fauty and Yulin Fang and Lora L Hamuro and Azher Hussain and Thomayant Prueksaritanont},
  journal={mAbs},
  year={2014},
  volume={6 2},
  pages={502-8}
}
The neonatal Fc receptor (FcRn) plays a pivotal role in IgG homeostasis, i.e., it salvages IgG antibodies from lysosomal degradation following fluid-phase pinocytosis, thus preventing rapid systemic elimination of IgG. Recombinant therapeutic antibodies are typically composed of human or humanized sequences, and their biodistribution, or tissue distribution, is often studied in murine models, although, the effect of FcRn on tissue distribution of human IgG in rodents has not been investigated… CONTINUE READING