The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide

@article{Conley2004TheEO,
  title={The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide},
  author={Barbara A. Conley and Gerald F. Sewack and Merrill J. Egorin and Babu Subramanyam and John G. Page and Charles K. Grieshaber},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={28},
  pages={33-38}
}
SummaryThe acute toxicities of the cellular differentiating agent hexamethylene bisacetamide (HMBA) in humans and animals include CNS toxicity (agitation, somnolence, seizures, hallucinations) and an anion-gap metabolic acidosis,N-Acetyl-1,6-diaminohexane (NADAH), the first metabolite of HMBA, is as active as the parent compound in causing differentiation of leukemic cells in vitro, whereas 6-acetamidohexanoic acid (6AcHA), which is formed by the oxidation of NADAH in the presence of monoamine… 

Amide exchange reaction: a simple and efficient CuO catalyst for diacetamide synthesis

A highly copper-catalysed amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O for the synthesis of hexamethylenebisacetamide (HMBA) without an organic solvent or gas protection

m6A RNA Methylation Regulators Impact Prognosis and Tumor Microenvironment in Renal Papillary Cell Carcinoma

A two-gene prognostic risk model including IGF2BP3 and HNRNPC was constructed and could predict overall survival of PRCC patients from the Cancer Genome Atlas dataset and predicted the three most significant small molecule drugs that potentially inhibit PRCC.

Approaches to optimal dosing of hexamethylene bisacetamide

Whether exposure to HMBA could be individualized and maximized without resulting in intolerable toxicity to patients was investigated and which factors would predispose a patient to the development of acute toxicity during treatment with HMBA were determined.

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