The effect of the low blink rate in rabbits on topical drug penetration.

  title={The effect of the low blink rate in rabbits on topical drug penetration.},
  author={David M Maurice},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  volume={11 3},
  • David M Maurice
  • Published 1995 in
    Journal of ocular pharmacology and therapeutics…
PURPOSE The low rate of blinking in the rabbit as compared to the human suggests that there may be a greater contact time for drugs applied topically in the animal. However, there have been no experiments performed to examine this belief directly. METHODS A small drop containing either fluorescein or FITC Dextran was applied to the eye of a rabbit without the use of tranquilizer or anesthetic. Subsequently, the change in the fluorescence of the precorneal tear film was followed with a… CONTINUE READING
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