The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin

@article{Davies1996TheEO,
  title={The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin},
  author={Holly G. Davies and Rebecca J. Richter and Matthew Keifer and Clarence A. Broomfield and Jason Sowalla and Clement E. Furlong},
  journal={Nature Genetics},
  year={1996},
  volume={14},
  pages={334-336}
}
Many organophosphorus compounds (OPs) are potent cholinesterase inhibitors, accounting for their use as insecticides and, unfortunately, also as nerve agents. Each year there are approximately 3 million pesticide poisonings world-wide resulting in 220,00 deaths1–2. In 1990, there were 1.36 million kg of chlorpyrifos, 4.67 million kg of diazinon and 1.23 million kg of ethyl parathion manufactured in the USA (data supplied by the USEPA). In addition to exposure risks during pesticide… CONTINUE READING
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