The effect of the enkephalin DADLE on transcription does not depend on opioid receptors

@article{Baldelli2006TheEO,
  title={The effect of the enkephalin DADLE on transcription does not depend on opioid receptors},
  author={Beatrice Baldelli and Lorella Vecchio and Maria Grazia Bottone and Giovanni Muzzonigro and Marco Biggiogera and Manuela Malatesta},
  journal={Histochemistry and Cell Biology},
  year={2006},
  volume={126},
  pages={189-197}
}
[D-Ala2,D-Leu5] enkephalin (DADLE) is a synthetic peptide capable of inducing a hibernation-like state in mammals in vivo and in cultured cells in vitro. The effects of DADLE seem to be due to its binding to opioid receptors; however, it inhibits the growth of LNCaP cells, devoid of opioid receptors. We have investigated the effects of DADLE on this cell line using transmission electron microscopy, immunocytochemistry and cytometry, in order to elucidate the general mechanism(s) by which this… CONTINUE READING