The effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepam.

@article{Ahonen1996TheEO,
  title={The effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepam.},
  author={Jouni Ahonen and Klaus T. Olkkola and Pertti J Neuvonen},
  journal={Fundamental & clinical pharmacology},
  year={1996},
  volume={10 3},
  pages={314-8}
}
The azole antimycotic itraconazole is a potent and relatively unspecific inhibitor of cytochrome P450 enzymes and has a potentially dangerous interaction with midazolam and triazolam. The possible interaction between itraconazole and diazepam was investigated in a double-blind, randomized, cross-over study. Ten healthy volunteers were given orally placebo… CONTINUE READING