The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.

@article{Engelhard2003TheEO,
  title={The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.},
  author={Kristin Engelhard and Christian Werner and Eva Ebersp{\"a}cher and Monika Bachl and Manfred Blobner and Eberhard Hildt and Peter J. S. Hutzler and Eberhard F. Kochs},
  journal={Anesthesia and analgesia},
  year={2003},
  volume={96 2},
  pages={524-31, table of contents}
}
In this study, we investigated whether the neuroprotection previously seen with dexmedetomidine or S(+)-ketamine involves regulation of proapoptotic (Bax and p53) and antiapoptotic (Bcl-2 and Mdm-2) proteins. Rats were anesthetized with isoflurane. After surgical preparation of isoflurane was discontinued, animals were randomly assigned to receive fentanyl… CONTINUE READING