The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.

@article{Terali2013TheEO,
  title={The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.},
  author={Kerem Terali and Rebecca L. Beavil and Richard W Pickersgill and Mark van der Giezen},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={440 2},
  pages={235-40}
}
Small inorganic assemblies of alternating ferrous/ferric iron and sulphide ions, so-called iron-sulphur (Fe-S) clusters, are possibly nature's most ancient prosthetic groups. One of the early actors in Fe-S cluster biosynthesis is a protein complex composed of a cysteine desulphurase, Nfs1, and its functional binding partner, Isd11. Although the essential function of Nfs1·Isd11 in the liberation of elemental sulphur from free cysteine is well established, little is known about its structure… CONTINUE READING