The effect of the MHC locus on autoantibodies in type 1 diabetes.


OBJECTIVE To investigate whether the presence of autoantibodies specific for type 1 diabetes (T1D) is determined by the major genetic susceptibility locus for the disease at the HLA genes, using the T1D Genetics Consortium data. METHODS We analysed anti-IA-2 and anti-GAD 65 autoantibody data from 2282 T1D patients from 1117 multiplex families. HLA… (More)
DOI: 10.1136/jmg.2009.066647


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