The effect of the CYP2C19 genotype on the hydroxylation index of omeprazole in South Indians

@article{Rosemary2004TheEO,
  title={The effect of the CYP2C19 genotype on the hydroxylation index of omeprazole in South Indians},
  author={J. Rosemary and Chandrasekaran Adithan and Nagatham Padmaja and Chanolean Shashindran and Nathalie G{\'e}rard and Rajagopal Krishnamoorthy},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={61},
  pages={19-23}
}
To investigate the relationship between CYP2C19 genotypes and the hydroxylation index (HI) of omeprazole in the South Indian population. Healthy unrelated South Indian subjects (n=300) were separated into three groups based on their CYP2C19 genotypes. They were administered a single oral dose of 20 mg omeprazole, and venous blood was collected 3 h later. Plasma was assayed using reversed-phase high-performance liquid chromatography, and the omeprazole HI was calculated. The means of HIs in… CONTINUE READING

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Mentioned Connections BETA
ExonsNo subtypeIntrons
This could be due to an additional mutation , either in the exons / introns or in the 5′-regulatory region of the CYP2C19 gene .
IntronsNo subtypeExons
This could be due to an additional mutation , either in the exons / introns or in the 5′-regulatory region of the CYP2C19 gene .
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