The effect of terpenes on percutaneous absorption of tiaprofenic acid gel

@article{Okyar2010TheEO,
  title={The effect of terpenes on percutaneous absorption of tiaprofenic acid gel},
  author={Alper Okyar and Maksat Nuriyev and Ayca Yildiz and Zeliha Pala-Kara and Narin Ozturk and Engin Kaptan},
  journal={Archives of Pharmacal Research},
  year={2010},
  volume={33},
  pages={1781-1788}
}
Tiaprofenic acid is a potent analgesic and nonsteroidal anti-inflammatory drug (NSAID) and like any other nonsteroidal anti-inflammatory drug, oral administration of the conventional dosage forms of tiaprofenic acid invariably causes gastrointestinal side effects. In an effort to eliminate these side effects while enhancing the drug concentration at the target tissue, an epidermal application of tiaprofenic acid seems to be an effective alternative drug delivery modality. This study attempts to… Expand
Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs
TLDR
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed drug groups used dermally or systemically in treatment of various rheumatic diseases, as well as for osteoarthritis, low back pain and some joint diseases. Expand
Terpenes and Essential Oils as Skin Penetration Enhancers
Percutaneous drug delivery is beset with an outstanding and inevitable challenge in the form of the stratum corneum – a natural skin barrier which regulates the influx of foreign substances into theExpand
Topical Delivery of Aceclofenac: Challenges and Promises of Novel Drug Delivery Systems
TLDR
Aceclofenac (ACE) was developed by its chemical modification and possesses superior efficacy but is not completely devoid of the NSAID-tagged side effects, and is justified to deliver ACE employing tools of drug delivery and nanotechnology to refine its safety profile. Expand
Gold Nanoparticle Penetration and Reduced Metabolism in Human Skin by Toluene
TLDR
Gold nanoparticles, 15 nm, in aqueous solution aggregated on the skin surface showed enhanced permeability to nanoparticles in the AuNP-TOL group with MPT and FLIM imaging to stratum spinosum of epidermis, of value to nanotoxicology. Expand
Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti‐inflammatory effect of celecoxib
The aim of this article was to use copaiba oil (C.O) to improve skin permeability and topical anti‐inflammatory activity of celecoxib (Cxb).
Analysis of essential oils isolated by steam distillation from Swinglea glutinosa fruits and leaves
Essential oils obtained by steam distillation from Swinglea glutinosa (Blanco) Merr. fruit peel or leaves were analyzed by gas chromatography with flame ionization and mass spectrometry detectionExpand

References

SHOWING 1-10 OF 24 REFERENCES
Evaluation of percutaneous absorption of midazolam by terpenes.
TLDR
D-limonene in combination with ethanol can be used to enhance the percutaneous absorption of the highly lipophilic drug midazolam. Expand
In Vitro and Ex Vivo Permeation Studies of Etodolac from Hydrophilic Gels and Effect of Terpenes as Enhancers
TLDR
Dermal application of etodolac seems to be an ideal route for administration and the lipophilicity of the enhancers seems an important factor in promoting penetration of etdolac through the skin. Expand
Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers
  • N. Davies
  • Chemistry, Medicine
  • Clinical pharmacokinetics
  • 1996
TLDR
The synovium is the proposed site of action of NSAIDs when used for musculoskeletal disorders, and substantial concentrations of tiaprofenic acid are attained in synovial fluid, and recent data suggest the possibility of stereoselective distribution of tiapsic acid intosynovium and cartilage. Expand
The Effect of Mixed-Solvent and Terpenes on Percutaneous Absorption of Meloxicam Gel
TLDR
The result showed that the solubility of meloxicam was dependent on the pH value of buffer solution and the enhancement effects of terpenes on drug precautious absorption showed menthol showed the greatest effect. Expand
Vehicle effects on in vitro release of tiaprofenic acid from different topical formulations.
TLDR
Results indicated that Carbopol 940 gel base is a good candidate for the topical delivery of TA, giving significantly higher drug release than the other vehicles. Expand
Effect of nerodilol, carvone and anethole on the in vitro transdermal delivery of selegiline hydrochloride.
TLDR
It is concluded that the terpene nerodilol, carvone and anethole produced a marked penetration enhancing effect on the in vitro transdermal delivery of selegiline hydrochloride that could possibly be used in the formulation of membrane-moderated TTS. Expand
Effect of formulation variables on the percutaneous permeation of ketoprofen from gel formulations.
TLDR
Ethanol had a synergistic effect on the enhancing activity of the terpenes and increasing the concentration of ethanol from 10% to 50% was associated with an increase in the permeation of ketoprofen. Expand
Percutaneous Permeation Enhancement by Terpenes: Mechanistic View
TLDR
Terpenes are included in the list of Generally Recognized As Safe (GRAS) substances and have low irritancy potential, so they appear to offer great promise for use in transdermal formulations. Expand
The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities.
TLDR
The four terpene enhancers produced linear relationships, indicating that they were more effective at enhancing the penetration of hydrophilic drugs rather than lipophilic drugs. Expand
Formulation development of transdermal dosage forms: quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin.
  • L. Kang, C. Yap, +5 authors S. Chan
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
  • 2007
TLDR
It is suggested that an ideal terpene enhancer should possess at least one or combinations of the following properties: hydrophobic, in liquid form at room temperature, with an ester or aldehyde but not acid functional group, and is neither a triterpene nor tetraterpene. Expand
...
1
2
3
...