The effect of temporal variation in biochemical markers of trisomy 21 across the first and second trimesters of pregnancy on the estimation of individual patient-specific risks and detection rates for Down's syndrome.

@article{Spencer2003TheEO,
  title={The effect of temporal variation in biochemical markers of trisomy 21 across the first and second trimesters of pregnancy on the estimation of individual patient-specific risks and detection rates for Down's syndrome.},
  author={Kevin Sim{\~o}es Spencer and Jennifer A. Crossley and David A. Aitken and Arthur B J Nix and F. D. J. Dunstan and Kaye J. Williams},
  journal={Annals of clinical biochemistry},
  year={2003},
  volume={40 Pt 3},
  pages={219-31}
}
BACKGROUND In a previous study we examined the changes in the median multiple of the median (MoM) with gestation of free beta human chorionic gonadotrophin (F beta-hCG), total human chorionic gonadotrophin (ThCG), alpha-fetoprotein (AFP) and pregnancy-associated plasma protein A (PAPP-A) in a large series of Down's syndrome pregnancies. Results showed that there was a significant temporal variation of the MoM for each marker. In this paper, we assess the impact of this temporal shift on the… CONTINUE READING
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Detection rates and false positive rate for Down syndrome screening : how accurately can they be estimated and what factors in  uence their value ?

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