The effect of taurine chloramine on pro-inflammatory cytokine production by peripheral blood mononuclear cells isolated from rheumatoid arthritis and osteoarthritis patients.

@article{ChorazyMassalska2004TheEO,
  title={The effect of taurine chloramine on pro-inflammatory cytokine production by peripheral blood mononuclear cells isolated from rheumatoid arthritis and osteoarthritis patients.},
  author={Magdalena Chorazy-Massalska and Ewa Kontny and A Kornatka and Maria Rell-Bakalarska and Janusz Marcinkiewicz and Wlodzimierz Maśliński},
  journal={Clinical and experimental rheumatology},
  year={2004},
  volume={22 6},
  pages={692-8}
}
OBJECTIVE Pro-inflammatory cytokines play a critical role in the pathogenesis of RA. A natural oxidant, TauCl exerts anti-inflammatory activities. Here, the effects of Tau and TauCl on key pro-inflammatory cytokines--IL-1beta, IL-6 and TNF-alpha production by LPS-triggered peripheral blood mononuclear cells (PBMCs) isolated from RA and OA patients and healthy blood donors--were examined. METHODS PBMCs were stimulated with LPS (24 h) in the presence of Tau or TauCl (200-400 microM). Cytokine… CONTINUE READING

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