The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.

@article{Tao2006TheEO,
  title={The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.},
  author={X Tao and Angela M. H. Brodie and Ivo P. Nnane},
  journal={Biopharmaceutics & drug disposition},
  year={2006},
  volume={27 7},
  pages={335-44}
}
The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-2.0 mg/kg) after single i.v. doses were analysed by the non-compartment model with terminal half-lives (t(1/2,lambdaz)) ranging from 34.3 to 37.5 h. The volume of distribution at the terminal phases… CONTINUE READING

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