The effect of substitution pattern of HPMC on polymer release from matrix tablets.

Abstract

The purpose of this study was to gain further understanding of how the substituent heterogeneity of hydroxypropyl methylcellulose, HPMC, affects the polymer release from hydrophilic matrix tablets. The hypothesis was that the heterogeneous substituent pattern facilitated hydrophobic interactions that increased the viscosity and therefore affected the… (More)
DOI: 10.1016/j.ijpharm.2010.01.029

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