The effect of substance P on proliferation and proteoglycan deposition of cells derived from rabbit intervertebral disc.


STUDY DESIGN This study is an in vitro investigation of the effects of substance P on intervertebral disc cell metabolism. OBJECTIVES To determine whether the neuropeptide, substance P, affects cells isolated from the intervertebral disc. SUMMARY OF THE BACKGROUND DATA Nerve fibers containing substance P are present in the anulus fibrosus and may be… (More)


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