The effect of steroids on lymphocyte profile in primary chronic glomerulonephritis. Empirical or tailored therapy?

@article{Gluhovschi2007TheEO,
  title={The effect of steroids on lymphocyte profile in primary chronic glomerulonephritis. Empirical or tailored therapy?},
  author={Cristina Gluhovschi and Gheorghe Gluhovschi and Diana Herman and Elena Potencz and Virginia Trandafirescu and A. Arthur Schiller and Ligia Petrica and Silvia Maria Velciov and G. Nicholas Bozdog and Flaviu Bob and Calin Muntean and Corina Vernic and Valentin Guset and Daniel Cioca},
  journal={International immunopharmacology},
  year={2007},
  volume={7 9},
  pages={
          1265-70
        }
}
Steroids are still the mainstay of therapy in primary chronic glomerulonephritis (PCGN), regardless of underlying disturbance or pathology. Moreover, relationship between known abnormalities and disease manifestation is stochastic, therefore treatment continues to be empirical. It is not known whether responsiveness is related to immune phenotype. We performed flowcytometric lymphocyte (Ly) phenotyping (CD19, CD3, CD3CD4, CD3CD8, CD56/16) on 16 patients (pts) (12M, 4F), mean age 37.6+/-13 years… CONTINUE READING
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