The effect of steroid on myeloid leukemic cells: the potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis.

@article{Hisnmez2006TheEO,
  title={The effect of steroid on myeloid leukemic cells: the potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis.},
  author={G{\"o}n{\"u}l Hiçs{\"o}nmez},
  journal={Leukemia research},
  year={2006},
  volume={30 1},
  pages={
          60-8
        }
}
Several in vitro studies have shown that dexamethasone (Dex) and prednisolone can induce differentiation of some mouse and human myeloid leukemic cells to macrophages and granulocytes. Based on in vitro experiments, we have shown that short-course (3-7 days) high-dose methylprednisolone (HDMP) (20-30 mg/kg/day) treatment can induce differentiation of myeloid leukemic cells in vivo in children with different subtypes of acute myeloblastic leukemia (AML) (AML-M1, -M2, -M3, -M4, -M7). We have also… CONTINUE READING
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A randomized trial of dexamethasone before remission induction in de novo childhood acute lymphoblastic leukemia

  • MA Lopez-Hemandez, M Alvarado, J DeDiego, Borbolla-Escoboza, RM Jimenez, E Trueba
  • Haematologica
  • 2004

The poten tial effect of short - course high - dose steroid on the maturation apoptosis of leukemic cells in a child with acute megakaryobl leukemia

  • G Hiçsönmez, H Okur, E Erdemli, A G̈urgey
  • Leuk Lymphoma
  • 2003

The role of shor course of high - dose methylprednisolone in children with a myeloblastic leukemia ( FAB M 2 ) presented with myeloid tum

  • G Hiçsönmez, D Aslan, E Özyürek
  • Pediatr Hematol Oncol
  • 2003

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