The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

@article{Pitt1999TheEO,
  title={The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.},
  author={Bertram Pitt and Faiez Zannad and Willem J. Remme and Robert J. Cody and Alain Castaigne and A. P{\'e}rez and Jolie Palensky and Janet Turk Wittes},
  journal={The New England journal of medicine},
  year={1999},
  volume={341 10},
  pages={
          709-17
        }
}
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663 patients who had severe heart failure and a left ventricular ejection fraction of no more than 35 percent and who were being treated with an angiotensin-converting-enzyme inhibitor, a loop diuretic, and in most cases digoxin. A total of 822 patients were randomly assigned to receive 25 mg of spironolactone daily, and 841 to receive placebo. The primary end point was… 

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