The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
@article{Pitt1999TheEO, title={The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.}, author={B. Pitt and F. Zannad and W. Remme and R. Cody and A. Castaigne and A. Perez and J. Palensky and J. Wittes}, journal={The New England journal of medicine}, year={1999}, volume={341 10}, pages={ 709-17 } }
BACKGROUND AND METHODS
Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663 patients who had severe heart failure and a left ventricular ejection fraction of no more than 35 percent and who were being treated with an angiotensin-converting-enzyme inhibitor, a loop diuretic, and in most cases digoxin. A total of 822 patients were randomly assigned to receive 25 mg of spironolactone daily, and 841 to receive placebo. The primary end point was… CONTINUE READING
Paper Mentions
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The purpose of this study is to determine if patients who receive an early radiofrequency
ablation will have fewer hospitalizations, unplanned office visits, and emergency room visits… Expand
Conditions | Heart Failure With Preserved Ejection Fraction |
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Intervention | Procedure |
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Hypertrophic Cardiomyopathy (HCM) is the most common hereditary heart disease with high
mortality. Heart failure is the most common complication (about 50% incidence) in these… Expand
Conditions | Fibrosis, Hypertrophic Cardiomyopathy |
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Intervention | Drug |
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In stage 3 chronic kidney disease (CKD) the risk of death due to cardiovascular causes is
high and greatly exceeds the risk of progression to end stage renal failure. This high… Expand
Conditions | Cardio-Renal Syndrome, Renal Insufficiency, Chronic |
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Intervention | Drug |
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